Adenosine-Related Mechanisms in Non-Adenosine Receptor Drugs

Role of Adenosine receptor in lung cancer

Summary: Adenosine through adenosine receptor have a crucial role in biology of lung cancer. Recent study indicated adenosine receptors have a crucial role in various aspect of lung cancer from cell growth and metastasis to modulation of apoptosis and it could be considered as a potential candidate for treatment of the lung cancer.

Receptor and non-receptor-dependent mechanisms of cardioprotection with adenosine.

The relative roles of mitochondrial (mito) ATP-sensitive K(+) (mitoK(ATP)) channels, protein kinase C (PKC), and adenosine kinase (AK) in adenosine-mediated protection were assessed in Langendorff-perfused mouse hearts subjected to 20-min ischemia and 45-min reperfusion. Control hearts recovered 72 +/- 3 mmHg of ventricular pressure (50% preischemia) and released 23 +/- 2 IU/g lactate dehydroge...

Adenosine inhibits IL-12 and TNF-[alpha] production via adenosine A2a receptor-dependent and independent mechanisms.

Interleukin 12 (IL-12) is a crucial cytokine in the regulation of T helper 1 vs. T helper 2 immune responses. In the present study, we investigated the effect of the endogenous purine nucleoside adenosine on the production of IL-12. In mouse macrophages, adenosine suppressed IL-12 production. Although the order of potency of adenosine receptor agonists suggested the involvement of A2a receptors...

Age-related changes in A(1)-adenosine receptor-mediated bradycardia.

The impact of age on functional sensitivity to A(1)-adenosine receptor activation was studied in Langendorff-perfused hearts from young (1-2 mo) and old (12-18 mo) male Wistar rats. Adenosine mediated bradycardia in young and old hearts, with sensitivity enhanced approximately 10-fold in old [negative logarithm of EC(50) (pEC(50)) = 4.56 +/- 0.11] versus young hearts (pEC(50) = 3.70 +/- 0. 09)....

Adenosine Receptor Antagonists(1)